The research conducted by Han et al. found that in patients with diabetes, a disease in the duration of ≥10 years, BMI < 18.5 kg/m2, and SDBG ≥ 3.0 mmol/L, and preoperative subcutaneous insulin injection is the main risk factor for perioperative hypoglycemia [18]. The gene discussed is INS; the disease is diabetes mellitus.