The Fibrosis-4 index (FIB-4) is a non-invasive tool of readily available clinical parameters (age, aspartate aminotransferase [AST], alanine aminotransferase [ALT], and platelet count) that, when compared to other non-invasive fibrosis markers, has shown to be highly effective in identifying advanced fibrosis in patients with NAFLD (19, 20). The gene discussed is GPT; the disease is metabolic dysfunction-associated steatotic liver disease.