With regard to the analysis of clinicopathologic factors, the results of this study suggested that independent risk factors for LNM in CRC included poorer histologic grade, LVI and CEA; in addition, histologic grade (G3), histologic grade (mucin-producing subtype), depth of invasion(T3-T4), and LVI were associated with poor prognosis. This evidence concerns the gene CEACAM5 and colorectal carcinoma.