According to Kaplan-Meier plotter database, elevation of Hsp27 at the transcriptional level was associated significantly with a poor prognosis in breast cancer (HRs, 95% CIs for OS: 1.41, 1.16-1.71, P=5.6e-04; RFS: 1.36, 1.23-1.5, P=3.9e-09; DMFS: 1.26, 1.08-1.47, P=0.0031. This evidence concerns the gene HSPB1 and breast cancer.