Furthermore, motif analysis revealed that SRSF1 (P=1e-13) and KHRBSH1 (P=1e-14) were enriched in differential ES and IR events of DU145 cells, whereas the SRSF2 (P=1e-8) motif was detected in differential ES and IR events for LNCaP cells (Figure 4G), indicating that different mechanisms may be involved in the two PCa cell lines. This evidence concerns the gene SRSF2 and posterior cortical atrophy.