Furthermore, markers reported to be relevant for adaptive immune responses (CALR, CLEC2B, AP2S1, and CCL27) and genes encoding for interleukin signaling molecules (NMU, IL18, and HMGV1) showed increased expression, and a high number of KCs from Der p 2 rec- and Der p 2 pep-treated AD skin were expressing these genes. The gene discussed is AP2S1; the disease is Alzheimer disease.