IGHE and Alzheimer disease: In this study, we compared the ability of the recombinant HDM allergen Der p 2 and a mix of hypoallergenic Der p 2 peptides, which lack IgE reactivity and do not induce basophil activation (Huang et al., 2019), to induce skin inflammation in both AD patients and healthy participants using single-cell RNA sequencing (scRNA-seq).