TOP2A and Alzheimer disease: Interestingly, a plethora of cell cycle and mitotic genes were upregulated in KCs from AD patients exposed to Der p 2 pep (Figure 5A, blue rectangle), such as DNA topoisomerase 2 (TOP2A) and centromere protein F (CENPF), which are important for chromosome segregation in mitosis; cytoskeletal genes such as tubulin beta (TUBB2); microtubule-stabilizing NUSAP1 and microtubule-destabilizing stathmin (STMN1); the cyclin-dependent kinase CKS2; and CDC20, UBE2C, and UBE2S, which encode for anaphase-promoting complex/cyclosome-regulating genes.