Furthermore, unbiased DEG analysis comparing PT cells from CKD samples by estimated GFR (eGFR 20-29 ml/min versus eGFR > 60 ml/min) revealed a significant up-regulation of multiple HLA-related genes including CD74 and HLA-DRB1 in kidneys with reduced filtration (Figures 3H–J). Here, CD74 is linked to chronic kidney disease.