CD8A and neoplasm: found that increased potassium levels in the TME reduce nutrient uptake by CD8+ T cells, activating autophagy and promoting metabolic reprogramming towards OXPHOS, which preferentially utilizes acetyl coenzyme A. Reduced acetyl coenzyme A content results in decreased histone acetylation at effector and exhaustion loci, leading to increased T cell stemness, reduced T cell exhaustion, and enhanced tumor control (69).