Apigenin is the most widely distributed and most studied flavone that has effects on diabetes, cancer, Alzheimer’s disease, amnesia (19), and also fibrosis (20, 39) through modulation of the cell-signaling pathways such as PI3K-AKT-GSK3, JAK-STAT, and MAPK signaling (40). This evidence concerns the gene AKT1 and fibrosis.