AKT1 and early-onset autosomal dominant Alzheimer disease: Apigenin is the most widely distributed and most studied flavone that has effects on diabetes, cancer, Alzheimer’s disease, amnesia (19), and also fibrosis (20, 39) through modulation of the cell-signaling pathways such as PI3K-AKT-GSK3, JAK-STAT, and MAPK signaling (40).