Peanut-specific serum IgG2a and IgG2b↑, IgE↓IL-10 and IFN-γ↑, IL-4, IL-5, IL-21 ↓ in spleen and mesenteric lymph nodeClinical anaphylaxis symptom score and temperature drop upon oral challenge ↓MCP-1 upon oral challenge↓Ear swelling and SPT wheal diameter upon intradermal challenge ↓Eosinophil and mast cell infiltration in the intestine ↓. The gene discussed is IL21; the disease is anaphylaxis.