The visualization results of heat maps revealed an elevation in the overall information flow from CD8+ T cell, DC, and macrophage clusters in both colon and rectal cancer tissues, the most significant increase in the information flow from macrophages in colon cancer tissues, and a dominant increase in the information flow from CD8+ T cells in rectal cancer tissues (Figure 7F). The gene discussed is CD8A; the disease is malignant colon neoplasm.