CD274 and neoplasm: Guo proved that hexokinase 2 can be used as a protein kinase to phosphorylate the Thr291 site of IκBα, thereby promoting combined protease u-calpain and IκBα and degrading IκBα, in turn promoting the entry of the NF-κB transcription subunit into the nucleus and the PD-L1 expression, ultimately leading to the immune escape of the tumor (33).