This rapidly induced neuroplasticity is mediated via the stimulation of TrkB, mTOR, and intracellular 5-HT2A signaling pathways and is thought to be essential to the therapeutic effects of ibogaine and other psychoplastogens on complex mental health conditions, such as depression and SUD (Ly et al., 2018; Vargas et al., 2023). Here, MTOR is linked to major depressive disorder.