KEGG signaling pathway enrichment analysis showed that A. manihot L. was involved in the regulation of PI3K/AKT signaling pathway, FoxO signaling pathway, VEGF signaling pathway, HIF-1, TNF signaling pathway, melanoma, hepatitis B, and other signaling pathways, which were closely related to the pathogenesis of CIN. This evidence concerns the gene VEGFA and melanoma.