KEGG signaling pathway enrichment analysis showed that A. manihot L. was involved in the regulation of PI3K/AKT signaling pathway, FoxO signaling pathway, VEGF signaling pathway, HIF-1, TNF signaling pathway, melanoma, hepatitis B, and other signaling pathways, which were closely related to the pathogenesis of CIN. The gene discussed is AKT1; the disease is melanoma.