The therapeutic effect of A. manihot L. on CIN may be related to the negative regulation of apoptosis, protein autophosphorylation, positive regulation of protein kinase B signal transduction, transmembrane receptor protein tyrosine kinase signaling pathway, cell proliferation, oxidative stress, MAPK activation and so on. The gene discussed is AKT1; the disease is cervical squamous intraepithelial neoplasia.