SLC22A8 and acute kidney injury: AKI is associated with downregulation of organic acid transporters (OAT) at the renal tubular level (OAT 1, OAT3) and at the brain level (OAT3), this lead to reduction in uraemic toxin renal excretion and reduces the efflux of drugs and organic solutes from the brain, respectively, leading to increasing the risk of drug accumulation and toxicity (4, 14).