68 UACR-associated loci, with PheWAS revealing associations with proteinuria, hyperlipidaemia, gout, and hypertension. Differential expression levels (RNA or protein) observed for UACR-associated genes in the kidney. Knockdown of prioritised genes (OAF and PRKCI) in Drosophila nephrocytes reduced albumin endocytosis, highlighting novel pathways potentially important for albuminuria. This evidence concerns the gene PRKCI and hypertensive disorder.