Identified associations between differential methylation and T1D-ESKD. Eight top-ranked genes showed eQTL support in a T2D cohort. 13 genes were supported by gene expression and/or methylation data from kidney tubule or glomerular tissues. Top-ranked enrichment pathways included cancer, TGF-β signalling and Th17 cell differentiation. Here, TGFB1 is linked to cancer.