Increased VCAM1+ injured proximal tubule cells in DKD. These cells present pro-inflammatory expression and transcription factor motifs involved in NF-κB signalling. Allele-specific chromatin changes associated with GFR. Differentially accessible regions enriched for glucocorticoid receptor motifs. Altered chromatin accessibility potentially alters cellular responses during DKD. The gene discussed is RAPGEF5; the disease is diabetic kidney disease.