68 UACR-associated loci, with PheWAS revealing associations with proteinuria, hyperlipidaemia, gout, and hypertension. Differential expression levels (RNA or protein) observed for UACR-associated genes in the kidney. Knockdown of prioritised genes (OAF and PRKCI) in Drosophila nephrocytes reduced albumin endocytosis, highlighting novel pathways potentially important for albuminuria. The gene discussed is OAF; the disease is hypertensive disorder.