Mean serum levels (95% confidence intervals) of soluble NKG2DLs in 308 incident HD patients without a cancer history were 0.072 (0.015-0.130) ng/mL, 0.742 (0.593-0.891) ng/mL, 327 (300-342) ng/mL, 0.444 (0.396-0491) ng/mL, and 0.118 (0.012-0.224) ng/mL, respectively in MICA, MICB, ULBP-1, ULBP-2, and ULBP-3. The gene discussed is MICB; the disease is cancer.