For example, in one large-sized study (205 leukemia patients and 30 healthy controls), there were significantly elevated levels of soluble MICA, MICB, ULBP-1, ULBP-2 and ULBP-3 in all leukemia entities except soluble ULBP-2 in chronic myeloid leukemia (CML), soluble ULBP-3 in chronic lymphocytic leukemia (CLL), and soluble ULBP-1 in acute myeloid leukemia (AML) (28). This evidence concerns the gene ULBP3 and chronic myelogenous leukemia, BCR-ABL1 positive.