NPPB and hydrops fetalis: The hematocrit levels of untreated HF rats were lower than those of sham-operated rats, Empagliflozin treatment restored the hematocrit of HF rats to levels similar to those of sham-operated rats, restored the blood volume of HF rats, and improved renal handling of sodium and water, as evidenced by normalization of hematocrit and serum brain natriuretic peptide (BNP) levels.