Hold ICI therapyStrongly consider kidney biopsy to confirm diagnosis unless contraindications are present.Biopsy confirm ICI-AKI may start prednisone 0.8-1mg/kg/day (max. 60-80 mg/day) and taper as bellow ***, pulse-dose i.v. corticosteroids (e.g., methylprednisolone, 0.5-1 g/day) for 2 to 3 days usually for patients with stage 3 AKI, followed by oral prednisone; checking CBC, CMP, UA, CRP, proteinuria/Cr in a week and if stable/improving recheck in one month and at the end of taper (approximately 8 weeks total treatment time). This evidence concerns the gene CRP and acute kidney injury.