CDKN2A and head and neck cancer: Sore throat and neck mass, as presenting symptoms were significantly the most common in oropharyngeal cancers, and further analyzed by p16-status, HPV-positive cancer patients presented 3 times more common with neck lump as an initial sign of disease, which phenomenon is due to the often rapidly growing, cystic neck metastases of HPV-related head and neck cancers [13].