PTP4A3 and cancer: ,9,10,11 PRL3 has been reported to be an excellent oncotarget, with expression in 80.6% of tumors across a broad range of cancer types but not in any adjacent normal tissue.10,11 PRL3 is undetectable in the major normal human organs.10 However, most studies have evaluated PRL3 expression in epithelial carcinomas more commonly found in adult patients, while the profile of PRL3 expression in pediatric cancers remains poorly understood.