Expression of angiogenin, TIMP1, and TIMP2 was specifically elevated in the PRL3-positive tumor specimens but not in PRL3-negative adjacent normal tissues (Figure 4A), with normalized net expression of these angiogenic factors increased in neuroblastoma, leiomyosarcoma, and rhabdomyosarcoma tumors (Figure S1). This evidence concerns the gene TIMP1 and neuroblastoma.