Expression of angiogenin, TIMP1, and TIMP2 was specifically elevated in the PRL3-positive tumor specimens but not in PRL3-negative adjacent normal tissues (Figure 4A), with normalized net expression of these angiogenic factors increased in neuroblastoma, leiomyosarcoma, and rhabdomyosarcoma tumors (Figure S1). The gene discussed is TIMP1; the disease is neoplasm.