INS and Insulin resistance: Regarding the mechanisms between T2DM and NAFLD, there is a close pathophysiological link between these ailments for which hepatic insulin resistance is likely the central tenet by raising hepatic TG synthesis triggered by fatty acids released from insulin-resistant adipocytes and De Novo Lipogenesis, whose latter process consists of elevated glycerol esterification of glycerol upon increased gluconeogenesis and decreased glycogenesis (37, 38).