TNF and ulcerative colitis: Conversely, a pooled analysis of data from randomized trials assessing anti-TNF use in ulcerative colitis reported no significant differences in the efficacy of anti-TNF in both inducing and maintaining remission between the older cohort (≥60 years) and younger cohort (<60 years) (OR: 1.05; 95% CI: 0.33, 3.39) (21).