TNF and Crohn disease: A post hoc analysis of the Randomized Evaluation of an Algorithm for Crohn’s Treatment (REACT) study, including the subset of participants >60 years with Crohn’s disease, showed no differences in achieving corticosteroid-free clinical remission between early use of combination therapy (anti-TNF agent and thiopurines) and conventional treatment (<60 years, risk ratio [RR]: 1.06; 95% CI: 0.98, 1.15; ≥60 years, RR: 1.09; 95% CI: 0.90, 1.33, P = 0.78) (23).