TNFRSF17 and Miyoshi myopathy: Rustad et al. (2020) reported the first comprehensive study of SVs in MM patients exploiting ONT. The authors identified three main patterns of SVs, chromothripsis, templated insertions, and chromoplexy, overall suggesting SVs as the missing piece to understand the driver landscape of MM. A total of 68 SV hotspots were identified, of which 53 were not previously reported. The characterization of the SV breakpoints revealed 17 new potential driver genes, among which TNFRSF17, SLAMF7, and MCL1 were the most relevant for their potential therapeutic impact.