The methylation data refer to the method described in Caputo et al. (2022b) that combines the methylation levels of four CpG sites (DUX4-PAS_CpG6, DUX4-PAS_CpG3, DR1_CpG1 and DR1_Cpg22) with machine-learning pipeline to classify FSHD subjects from non-FSHD ones (herein referred as to CTRL). The gene discussed is DUX4; the disease is Facioscapulohumeral dystrophy.