Soy intake was associated with reduced risk of ER+/progesterone receptor (PR)+ breast cancer in postmenopausal women (HR = 0.72, 95% CI: 0.53–0.96) and reduced risk of ER-/PR- breast cancer in premenopausal women (HR = 0.46, 95% CI: 0.22–0.97) [96]. This evidence concerns the gene ESR1 and breast cancer.