SLC2A5 and hereditary fructose intolerance: Consistent with this, mice with hepatic ChREBPdeficiency do not exhibit fructose intolerance [62].It was experimentally demonstrated that the ChREBP-MLX heterodimer binds directly to ChoRE,located 2 kb from the SLC2A5 gene (2149–2165), thereby regulating SLC2A5 transcription, and that this protein-DNA interaction is induced by diet [61].