The GLUT5 mRNA expression level was almost 2.5- foldshigher in the colonic mucosa of CRC patients than in the colonic mucosa of non-CRCcontrols ( P <0.001) [115].Moreover, treatment with the GLUT5-specific inhibitor MSNBA for 24 h significantlydecreased the viability of the human CRC cell line HT-29 (51% reduction at 10 ìM and 55%reduction at 1 ìM) but had a minimal effect on CCD 841 CoN in the human normal colonicepithelial cell line (8% reduction at 10 ìM and 2% reduction at 1 ìM) [115]. This evidence concerns the gene SLC2A5 and colorectal carcinoma.