Clinically, patients with FM will exhibittypical gastrointestinal symptoms with irritable bowel syndrome (IBS), such as diarrhea,abdominal distention, and abdominal pain [124].Indeed, approximately one-third of IBS patients are diagnosed with FM manifestations,whereas restricted fructose intake is able to alleviate their clinical symptoms [ 125– 127].Abnormalities in the major fructose transporters in the intestines are considered to beresponsible for the development of FM [61]. This evidence concerns the gene SLC2A5 and irritable bowel syndrome.