Considering the role of the demethylase FTO in regulating PPAR resistance in OC and the role of MEIS1 in suppressing oxaliplatin resistance and tumorigenesis in colorectal cancer, we performed colony forming, EdU and CCK-8 assays on A2780 cells with FTO knockdown to verify whether FTO could reverse OC cell proliferation and chemoresistance by modulating the RP5-991G20.1/hsa-miR-1976/MEIS1 signaling pathways. The gene discussed is MEIS1; the disease is colorectal cancer.