As shown in Figs. 9I and 10A-D, compared with the control group, FTO knockdown significantly enhanced the proliferation and cDDP and PPARi resistance of A2780 cells, simultaneously reducing the degree of apoptosis, indicating that FTO restrains the proliferation and drug resistance of OC cells, which further confirms the critical role of FTO in reversing ovarian cancer resistance and growth. Here, FTO is linked to ovarian carcinoma.