In A30P-mutant α-synuclein transgenic (Tg) mouse line which is a widely used genetic PD animal model [28, 41], a pronounced increase in RGS5 immunosignals was observed in GFAP+ astrocytes in the transgene compared to wild-type mice (Additional file 1: Fig. S1B, C). Here, RGS5 is linked to Parkinson disease.