We found that following selective overexpression of RGS5 in astrocytes (Fig. 2G), A30P-mutant α-synuclein Tg mice exhibited a rapid decline in motor function with the hind limbs most affected, as evidenced by a prominent reduction in grip strength with abnormal hind limb clasping in the pole test as compared with control (Fig. 2H), the behavioral phenotypes manifested in early stages of neurodegenerative disease [41, 47]. The gene discussed is RGS5; the disease is neurodegenerative disease.