ADAMTS13 and Genetic thrombotic microangiopathy: Decreased ADAMTS13 activity with TAMOF reflective of thrombotic microangiopathy [22] and increased circulating IL-10 reduced whole blood ex vivo TNF response to endotoxin, and immunoparalysis reflective of immune depression with reduced ability to kill infection [27, 28, 37] was also observed with increasing ferritin levels [20].