In the PD-L1-negative (PD-L1−) tumor cells, fewer infiltrating CD8+ T cells were surrounding PD-L1-negative and S15-positive (PD-L1− + S15+) tumor cells than PD-L1-negative and S15-negative (PD-L1− + S15−) tumor cells in different ranges (Fig. 4I). The gene discussed is CD274; the disease is neoplasm.