They effectively assessed tumor-infiltrating CD8 cells and immunotherapeutic response by CT radiomics in a variety of advanced solid tumors, and the radiomic signature of CD8 cells was validated in three additional independent cohorts, providing precise predictions for distinguishing the immunophenotypes of tumors and clinical outcomes of cancer patients undergoing anti-PD-1 and PD-L1 immunotherapy [43]. This evidence concerns the gene CD8A and neoplasm.