ELANE and asthma: It has also been reported in the literature that IL-17 and neutrophils induce airway smooth muscle proliferation by activating neutrophil elastase-related E-cadherin/β-catenin signaling [71], and in HDM-induced asthma models, MIF increases airway responsiveness by causing the disruption and delocalization of epithelial E-cadherin to increase airway responsiveness [49].