CFTR and colorectal carcinoma: Our results showed the marked ability of ETI to rescue CFTR function in all CRC-based in vitro models, confirming the results obtained for other L1077P-bearing genotypes (Patient 1 and Patient 2) and suggesting that other genotypes that bear the L1077P allele may be responding to the triple drug combination independently of the type of CFTR mutation that is present on the second allele.