In DLPFC, synaptic-enriched proteins included IGLON5, a neuronal adhesion molecule linked to neurological disorder characterized by sleep disorders and cognitive impairments; EPHA4 [134], a receptor tyrosine kinase that modulates aberrant synaptic functions in response to neuronal injury and neuroinflammation; and GPC1, a glycoprotein involved in extracellular matrix (ECM) formation. The gene discussed is IGLON5; the disease is Cognitive impairment.