UBA1 and hematologic disorder: First described by Beck et al. in 2020, VEXAS (vacuoles, E1 enzyme, X-linked, auto-inflammatory, somatic) syndrome is a rare and potentially lethal disease characterized by multi-system inflammatory and or hematological disorders caused by somatic mutations in ubiquitin activating enzyme 1 (UBA1) in hematopoietic progenitor cells [1].