HMMR and posterior cortical atrophy: In support of our findings, stable AR knockdown in PCa cells downregulated HMMR in an independent RNA-seq dataset (Supplementary Figure 1e) [23], and in patient-derived explants (PDEs), AR knockdown by siAR-loaded nanoparticles [22] reduced both AR and HMMR mRNA expression compared to control (Supplementary figure 1f).