Then, we performed a detailed T cell analysis, the results showed, after STING activation, the PD-1 expression was decreased in CD8+ T cells, moreover, the TEM subset (CD62L+ CD44−) of CD8+ T cells and the stemness of PD-1 positive CD8+ T cells was increased (Fig. 6k), indicating STING activation reshaped tumour-infiltrating T cells15. The gene discussed is STING1; the disease is neoplasm.