In TIOs+NIR1 + cGAMP4 treated 4T1 tumour bearing mice, four times cGAMP were injected intratumorally (Fig. 5f), compared with PBS-treated, cGAMP alone treated and TIOs+NIR1 treated mice, the tumour disappeared by treating with TIOs+NIR1 + cGAMP4 (Fig. 6i). The gene discussed is PITPNM3; the disease is neoplasm.