To define that mouse Aβ and Tau were indeed aggregated into the pathological inclusions in the brain, we conducted the immuno-EM (electron microscopy) analysis and found that AD fecal inoculation triggered both mouse Aβ and Tau accumulation (arrow) in WT mouse brain, and the immuno-activities were profoundly augmented in C/EBPβ transgenic mice (Fig. 1G), fitting with the IB findings. Here, MAPT is linked to Alzheimer disease.