LGMN and Alzheimer disease: To assess whether AD gut microbiota incurred AD-like pathologies implicated C/EBPβ/AEP signaling activation, we performed IB analysis and found that both C/EBPβ and p-C/EBPβ, a biomarker for its activation35, were elevated in WT mice upon AD fecal inoculation, which subsequently elicited AEP upregulation and activation.