Most recently, we report that C/EBPβ is escalated in neurons in an age-dependent manner and mediates APP, MAPT, and BACE1 mRNA expression, and mice with double transgenic expression of ApoE4 and C/EBPβ in neurons exhibit sporadic AD pathologies in Thy1-ApoE4/C/EBPβ mouse model24. Here, APP is linked to Alzheimer disease.