Most recently, we showed that AD-derived microbiota enhances the proinflammatory pathway for poly-unsaturated fatty acid (PUFA) metabolism, and Bacteroides strains mediating PUFA metabolism are increased in AD patient gut microbiomes, activating microglia in the brain, associated with C/EBPβ/AEP signaling activation11. The gene discussed is CEBPB; the disease is Alzheimer disease.