CSF1R and Alzheimer disease: To explore whether depletion of microglia confers protection in the AD inoculated mice, we fed Thy1-C/EBPβ Tg mice with PLX3397 (CSF1R Inhibitor)41 to delete microglia, followed by PGE2 treatment, and found that deletion of microglia from Thy1-C/EBPβ Tg mice attenuated PGE2-induced AD pathologies (Supplementary Fig. 16).