Notably, among all known ligand-receptor pairs, DMD collagen signaling was mainly dominated by collagen I, IV and VI and its receptor Itga1/Itga2 + Itgb1. FAPs were also the most prominent source of laminin either in control and DMD samples, although adipocytes became an important source as well in DMD (Fig. 8). Here, ITGA2 is linked to Duchenne muscular dystrophy.