RYR1 and Duchenne muscular dystrophy: Although the regenerative signature was predominant in the myofibers, we also identified upregulation of genes involved in the process of protein degradation, such as overexpression of the proteases Capn3 and Capn2 and calcium channels Ryr1 and Cacnas1s, two pathways suggested to be involved in the process of muscle degeneration in DMD [55, 56].