Fast and slow myofibers in DMD shared several genes in the top ten upregulated genes, such as Myh3, a characteristic marker of regenerative myofibers (log2FC = 3.1 and 2.1 respectively), Meg3, a LncRNA involved in myoblast plasticity and differentiation (log2FC = 2.3 and 2.9 respectively) and Ldb3 which acts as an adapter in skeletal muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton (log2FC = 1.6 and 1.3 respectively) (Fig. 3A–D) [35, 36]. The gene discussed is MYH3; the disease is Duchenne muscular dystrophy.