The differential expression of migraine susceptibility gene Naxe [43], mitochondrial transporter encoding genes Slc25a16 [44] and Slc25a51 [45], mitochondrial respiratory function related gene Sdnaf1 [46] and Cox11 [47], regulation of cholesterol biosynthesis gene Fdps [48], methyltransferase activity gene Comtd1 [49], regulation of apoptosis gene Endog [50], and Prss35 [51], a gene highly expressed in renal fibrosis, may be the compensatory increase after mitochondrial injury. This evidence concerns the gene COMTD1 and migraine disorder.