Notably, SARS-CoV-2 infection can increase the level of IL-1ɑ and IL-6 and decrease that of Th2 cells, Th17 cells, and Treg, which causes CD4 + , CD8 + T-cells, and activated CD4 + T-cells exhaustion i.e., lymphopenia. The gene discussed is CD4; the disease is lymphopenia.