The downregulated molecule KLF15 was noticed due to its high expression in human skeletal muscle but significant reduction in patients with various muscle diseases including juvenile dermatomyositis (JDM), amyotrophic lateral sclerosis (ALS), Becker muscular dystrophy (BMD), and Duchenne muscular dystrophy (DMD). This evidence concerns the gene KLF15 and Duchenne muscular dystrophy.