In the final assessment of the behavior function of PD mice using Y‐maze, open‐field, rotarod testing, and Morris water maze, the exogenous delivery of THBS1 CRISPRi showed promising results in mitigating the behavioral burden induced by the LRRK2 mutation in mice (Figure 7L–O), indicating targeting THBS1 could have a beneficial effect on improving motor and cognitive functions in the context of LRRK2‐related PD. Here, LRRK2 is linked to Parkinson disease.