The inhibitors of LRRK2 and antisense oligonucleotides in small molecules have been invented and are currently deemed safe for therapeutic usage.[4a] However, it is yet unknown how the activity of LRRK2 kinase is maintained at the cellular and molecular levels and how the abnormal activity of LRRK2 kinase correlates to PD. Here, LRRK2 is linked to Parkinson disease.