To circumvent this, given our previous work using the same infection model had shown that the zebrafish ortholog of C/EBPβ is expressed within Runx1-positive HSPCs 12 hours postinfection and drives the EG response (17), we next explored whether overexpressing cebpb in HSPCs was sufficient to enhance granulopoiesis and generate neutrophils with elevated bactericidal activity. This evidence concerns the gene RUNX1 and infection.