Published epithelial-specific SOX2-, KLF5-, or SOX2/KLF5-regulated gene programs (34, 35, 37) were enriched across EEC clusters in EoE, with the most dramatic increase in the suprabasal and superficial clusters (Figure 9G and Supplemental Tables 5 and 7). This evidence concerns the gene SOX2 and eosinophilic esophagitis.