Furthermore, in EoE, there was significant dysregulation of 224 genes known to be coregulated by the SOX2-KLF5 interaction (FDR-adjusted P < 0.05 and |logFC| > 0.25), with 86.7% of these genes showing upregulation (Supplemental Table 8). Here, SOX2 is linked to eosinophilic esophagitis.