In total, 1,620 genes known to be regulated by SOX2 and/or KLF5 were significantly upregulated in EEC in EoE (FDR-adjusted P < 0.05 and logFC > 0.25), 76.5% of which demonstrated the highest upregulation in the suprabasal and superficial compartments (Supplemental Table 7). The gene discussed is KLF5; the disease is eosinophilic esophagitis.