COL1A1 and osteogenesis imperfecta: This probably occurs, in part, due to the lack of space caused by growth problems of the maxilla, which is very common in OI,7 leading to a greater occurrence of impacted maxillary second molars.26 Another factor that may contribute to tooth impaction is the excessive bulbosity or volume of the crowns, which impairs the eruption process.21 Genetic analysis studies indicate that impacted teeth in individuals with OI are also associated with qualitative mutations in the COL1A1 / COL1A2 genes.26 , 32