The recently revised 5th edition of the WHO Classification of Hematolymphoid Tumors and the ICC now recognize the following groups: high-grade B-cell lymphoma (HGBCL) with MYC and BCL2 rearrangements (with or without BCL6 rearrangement, HGBCL-DH-BCL2) [1, 2], a provisional entity with MYC and BCL6 rearrangements (HGBCL-DH-BCL6) [1] and HGBCL-NOS. This evidence concerns the gene BCL2 and B-cell non-Hodgkin lymphoma.