SOD1 and obesity due to melanocortin 4 receptor deficiency: As reviewed by Wang et al., antioxidant supplementation may have positive effects on several indicators of obesity (BMI, HOMA-IR, or fasting blood glucose) and related components such as antioxidant capacity (MDA or SOD), inflammatory biomarkers (TNFα), and lipid metabolism (total cholesterol, triglycerides, or LDL) [169].