On the other hand, COX2 and endothelial NOS are predicted targets of miR-6796-5p/miR-4697-3p and miR-92a/miR-221/miR-222, respectively, which are known to be upregulated in MUO subjects, thereby pointing to a plausible role of these miRNAs in metabolic disease prevention in patients with obesity through OS reduction [145–147]. This evidence concerns the gene NOS3 and obesity due to melanocortin 4 receptor deficiency.