For example, among obesity genes reported in literature, IRF4 has a pronounced role in obesity-induced inflammation, supporting the BMI \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\to$$\end{document}→ GE causality [71]. This evidence concerns the gene IRF4 and obesity due to melanocortin 4 receptor deficiency.